Wholesale Price Natural Plant Extract Powder Rhubarb Root Extract Emodin 98% In Stock

Wholesale Price Natural Plant Extract Powder Rhubarb Root Extract Emodin 98% In Stock

Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone derivative and one of the primary bioactive components found in the roots of plants like rhubarb (Rheum palmatum, Rheum officinale), as well as in knotweed, senna, and aloe.

Primary Source: Rhubarb root (Chinese medicinal rhubarb, Da Huang) is a traditional and rich source.

Extraction: Typically obtained via solvent extraction (e.g., ethanol, methanol) followed by chromatographic purification. Modern techniques like ultrasonic-assisted or supercritical fluid extraction may also be used.

Emodin has been extensively studied for a wide range of biological effects:

Anticancer Properties:

Mechanisms: Induces apoptosis, inhibits cell proliferation, and suppresses metastasis in various cancer cell lines (e.g., breast, lung, liver, colon).

Pathways: Modulates key signaling pathways like PI3K/Akt, NF-κB, and STAT3.

Anti-inflammatory & Immunomodulatory Effects:

Inhibits the production of pro-inflammatory cytokines (e.g., TNF-α, IL-6).

Suppresses enzymes like cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).

Antimicrobial & Antiviral Activity:

Shows activity against bacteria (e.g., Staphylococcus aureus), fungi, and viruses.

Research has indicated potential against herpes simplex virus and hepatitis B virus.

Laxative Effect:

This is the most well-known traditional use of rhubarb extract. Emodin and other anthraquinones stimulate colonic peristalsis and increase intestinal water content, leading to a laxative effect. Note: Long-term use can lead to tolerance and potentially harmful side effects like electrolyte imbalance.

Renal & Cardiovascular Protection:

Some studies suggest protective effects against renal fibrosis and diabetic nephropathy.

May offer benefits for atherosclerosis and myocardial hypertrophy.